Polyamine functionalized carbon nanotubes: synthesis, characterization, cytotoxicity and siRNA binding was written by Singh, Prabhpreet;Samori, Cristian;Toma, Francesca Maria;Bussy, Cyrill;Nunes, Antonio;Al-Jamal, Khuloud T.;Menard-Moyon, Cecilia;Prato, Maurizio;Kostarelos, Kostas;Bianco, Alberto. And the article was included in Journal of Materials Chemistry in 2011.Computed Properties of C20H34N4O4 The following contents are mentioned in the article:
In this work the authors have synthesized a new series of cationic carbon nanotubes (CNTs) for siRNA binding. Both single- and multi-walled CNTs have been modified by addition or amidation reaction with short linear polyamine chains including putrescine, spermidine and spermine. All the new conjugates have been characterized with several spectroscopic and microscopic techniques. Their cytotoxic effects have been assessed on human lung carcinoma cell line. Finally, the authors have analyzed their capacity to bind siRNA towards the development of new carriers for gene silencing applications. The dispersibility properties and the capacity to complex siRNA of the different conjugates were strongly dependent on the position of the functional groups on CNTs (i.e. mainly at the tips following the amidation reaction or on the sidewalls by direct C-C addition). This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Computed Properties of C20H34N4O4).
Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Computed Properties of C20H34N4O4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts