(Bis)urea and (Bis)thiourea Inhibitors of Lysine-Specific Demethylase 1 as Epigenetic Modulators was written by Sharma, Shiv K.;Wu, Yu;Steinbergs, Nora;Crowley, Michael L.;Hanson, Allison S.;Casero, Robert A. Jr.;Woster, Patrick M.. And the article was included in Journal of Medicinal Chemistry in 2010.Computed Properties of C20H34N4O4 The following contents are mentioned in the article:
The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 overexpression is thought to contribute to the development of cancer. We recently reported a series of (bis)guanidines and (bis)biguanides that are potent inhibitors of LSD1 and induce the re-expression of aberrantly silenced tumor suppressor genes in tumor cells in vitro. We now report a series of isosteric ureas and thioureas that are also potent inhibitors of LSD1. These compounds induce increases in methylation at the histone 3 lysine 4 (H3K4) chromatin mark, a specific target of LSD1, in Calu-6 lung carcinoma cells. In addition, these analogs increase cellular levels of secreted frizzle-related proteins (SFRP) 2 and 5 and transcription factor GATA4. These compounds represent an important new series of epigenetic modulators with the potential for use as antitumor agents. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Computed Properties of C20H34N4O4).
Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Computed Properties of C20H34N4O4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts