Pang, Jiyan et al. published their research in Zhongguo Yaowu Huaxue Zazhi in 2002 | CAS: 123257-07-8

Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 123257-07-8

Synthesis and anti-inflammatory and analgesic activities of dihydropyrrolo[1,2-a]pyrazin-1-one was written by Pang, Jiyan;Sun, Guang;Fu, Decai;Sun, Shoufang. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2002.Recommanded Product: 123257-07-8 The following contents are mentioned in the article:

The structure-activity relationship (SAR) of the title compounds was studied to search for new anti-inflammatory and analgesic agents. 6-(R-carbonyl)-2-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ones (R = R’- Ph, R”-benzyl, or phenylethenyl; R’ = H, 4-Cl, 2-Cl, 2,4- dichloro, 4-Me, 4-Br, 4-F, 2-F, 4-methoxy, or 4-nitro; R” = H or Cl) were designed based on the known SAR. The 3,4-dihydropyrrolo[1,2-a]pyrazin-1-one moiety (II) was prepared from Me 2-pyrrolecarboxylate by N-alkylation, reduction, and cyclization. The Friedel-Crafts reaction of compound II with acyl chloride afforded the 6-aroyl derivatives The anti-inflammatory and analgesic activities were tested in mice. Thirteen of 6-aroyl-2-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1-ones were synthesized. Most of the compounds showed remarkable anti-inflammatory and/or analgesic activities in mice. The activities of one compound (R = 4-chlorophenyl) were equal to those of ibuprofen. This study involved multiple reactions and reactants, such as Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8Recommanded Product: 123257-07-8).

Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 123257-07-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts