Lange, Udo E. W. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2003 | CAS: 81698-03-5

5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Recommanded Product: 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile

D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety was written by Lange, Udo E. W.;Baucke, Dorit;Hornberger, Wilfried;Mack, Helmut;Seitz, Werner;Hoffken, H. Wolfgang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Recommanded Product: 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile The following contents are mentioned in the article:

Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity vs. trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures. This study involved multiple reactions and reactants, such as 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5Recommanded Product: 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile).

5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Recommanded Product: 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts