Synthesis and Biological Evaluation of s-Triazine Substituted Polyamines as Potential New Anti-Trypanosomal Drugs was written by Klenke, Burkhard;Stewart, Mhairi;Barrett, Michael P.;Brun, Reto;Gilbert, Ian H.. And the article was included in Journal of Medicinal Chemistry in 2001.Name: Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) The following contents are mentioned in the article:
The P2 transporter is a nucleoside transporter which is unique to the protozoan parasite Trypanosoma brucei, the causative organism of Human African Trypanosomiasis. The transporter has been shown to bind some structural motifs not recognized by other transporters. In this paper we describe the use of the melamine motif, a substrate of the P2 transporter, as a potential tool to selectively deliver polyamine analogs to the parasites. The synthesis of a number of polyamine analogs attached to a variety of melamine analogs is described. Many of the compounds were shown to competitively inhibit uptake of adenosine, indicating that they are recognized by the transporter. Some of the compounds showed good in vitro activity against the parasites. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Name: Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE)).
Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Name: Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE)
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts