Breaking the C3-Symmetry of Chiral Tripodal Oxazolines: Enantio-Discrimination of Chiral Organoammonium Ions was written by Kim, Jeongryul;Kim, Sung-Gon;Seong, Hye Ran;Ahn, Kyo Han. And the article was included in Journal of Organic Chemistry in 2005.Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile The following contents are mentioned in the article:
A phenylglycinol-derived tripodal oxazoline with C1-symmetry (C1-PhBTO) was synthesized, and its enantioselective recognition behavior toward α-chiral primary organoammonium ions was studied. The C1-PhBTO receptor showed higher selectivity with an opposite sense of enantio-discrimination compared to other C1-sym. analogs examined but lower selectivity with the same sense of enantioselection compared to its C3-sym. analog. Binding studies indicated that the C1-sym. receptors, particularly C1-PhBTO, interact with the guests in a 2:1 host-guest complex mode in stark contrast to its C3-sym. analogs. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile).
2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Safety of 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts