Cation selectivity of ionophores based on tripodal thiazole derivatives on benzene scaffold was written by Kim, Hong-Seok;Kim, Dong-Hyun;Kim, Ki Soo;Choi, Jun-Hyeak;Choi, Heung-Jin;Kim, Sung-Hoon;Shim, Jun Ho;Cha, Geun Sig;Nam, Hakhyun. And the article was included in Talanta in 2007.Synthetic Route of C15H15N3 The following contents are mentioned in the article:
The synthesis and potentiometric evaluation of new 1,3,5-tris(thiazolylcarbethoxy)-2,4,6-trimethylbenzene, 1,3,5-tris(thiazolylhydroxy)-2,4,6-trimethylbenzene, 1,3,5-tris(thiazolylmethyl)-2,4,6-trimethylbenzene, and 1,3,5-tris(thiazolylphenyl)-2,4,6-trimethylbenzene, toward mono and divalent cations under various pH conditions are outlined. The ion-selective properties of the newly synthesized compounds were studied by measuring the potentiometric responses of the 3-, 4-, 5-, and 6-based membrane electrodes to alkali metal, alk. earth metal, ammonium, and transition metal ions, under various pH conditions. The 3-based electrode exhibited a Nernstian response to ammonium and potassium under alk. pH conditions, while the other three electrodes showed a poor potentiometric performance. All electrodes showed substantial responses to silver ion under acidic condition, but there was almost nil response to other transition metal ions (Fe2+, Co2+, Zn2+, Ni2+, Pb2+, Cd2+, Cu2+ and Hg2+). The 3- and 5-based electrodes resulted in near Nernstian responses (51.3 mV and 59.5 mV/pAg+, resp.) with low detection limits (∼100 ppt), while the 4- and 6-based ones showed sub-Nernstian <40 mV/pAg+. The results were interpreted with semi-empirically modeled structures. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Synthetic Route of C15H15N3).
2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Synthetic Route of C15H15N3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts