Template Oligomerization of DNA-Bound Cations Produces Calibrated Nanometric Particles was written by Blessing, Thomas;Remy, Jean-Serge;Behr, Jean-Paul. And the article was included in Journal of the American Chemical Society in 1998.SDS of cas: 194808-59-8 The following contents are mentioned in the article:
A general approach to the monomol. condensation of DNA into stable nano-metric particles is reported, which may be extended to the design of any kind of calibrated nano-metric particles required for material sciences. The process takes advantage of the low cooperativity of binding small monomeric counterions to a macromol. polyion, followed by a zipper-oligomerization reaction which “freezes” the resulting condensed particles. The DNA particles have a neg. surface charge which ensures colloid stability and in vivo diffusion, yet makes them unsuitable for carrying DNA into cells. Thus, C-sper-C [cysteine-spermine-cysteine (I)] was synthesized and mixed with plasmid DNA, which was found to enhance the thiol oxidation rates in the thiol/disulfide oligomerization, which resulted in condensation of the DNA into particles of mean size 50 ± 15 nm, which were stable ≥1 wk. The condensed particles were stable in electrophoresis conditions, but addition of excess dithiothreitol of raising the ionic concentration to physiol. levels converted the cationic polymer back to I. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8SDS of cas: 194808-59-8).
Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).SDS of cas: 194808-59-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts