Potikha, L. M. published the artcileCondensed isoquinolines. 23. Reaction of [o-(bromomethyl)phenyl]acetonitrile with anthranilic acids: synthesis of 6H,12H,17H-dibenzo[3,4:6,7][1,8]naphthyridino[1,8-ab]quinazoline-6,17-diones, Application In Synthesis of 73217-11-5, the main research area is anthranilic acid cyclocondensation bromomethylbenzeneacetonitrile; isoquinoquinazolinone derivative preparation; dibenzonaphthyridinoquinazolinedione derivative preparation.
The direction of the reaction of anthranilic acids with [o-(bromomethyl)phenyl]acetonitrile upon fusion depends on the temperature and nature of the substituent in the anthranilic acid. The reaction may lead to three types of products: derivatives of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones below 150° and to 6,11-dihydro-13H-isoquino[3,2-b]quinazolin-13-ones, e.g., I, or 6H,12H,17H-dibenzo[3,4:6,7][1,8]naphthyridino[1,8-ab]quinazoline-6,17 -diones (II; R1 = H, Cl; R2 = H, Br, Cl) above 150° depending on the nature of the substituent in the anthranilic acid. A study was carried out on the mechanism for the formation of 6H,12H,17H-dibenzo[3,4:6,7][1,8]naphthyridino[1,8-ab]quinazoline-6,17 -diones, which permitted the preparation of 6-(4-methylphenyl)-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one (III).
Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Cyclocondensation reaction. 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Application In Synthesis of 73217-11-5.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts