Le, Thanh Nguyen published the artcileNovel synthesis of the natural protoberberine alkaloids: oxypalmatine and oxypseudopalmatine, Name: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is oxypalmatine oxypseudopalmatine protoberberine alkaloid synthesis cycloaddition nucleophilic substitution.
Oxypalmatine (I) and oxypseudopalmatine (II) were synthesized in three steps from the benzonitrile III and toluamides IV (R1 = OMe, R2 = H; R1 = H, R2 = OMe, resp.). The lithiated cycloaddition reaction yielded 3-arylisoquinolinone intermediates. A subsequent internal SN2 reaction produced the corresponding 8-oxoprotoberberines, oxypalmatine and oxypseudopalmatine.
Bulletin of the Korean Chemical Society published new progress about Cycloaddition reaction. 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Name: 2-Formyl-4,5-dimethoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts