Krasavin, Mikhail published the artcileDiscovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer, Application of 2,3-Dimethoxybenzonitrile, the main research area is structure activity relationship N aryl oxadiazol amine derivative antiproliferative; prostate carcinoma.
A new chem. series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency – 5.7 μM). Exploration of the two peripheral diversity vectors of the hit mol. in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the ‘best’ pharmacophoric moieties. The latter were merged in a single compound that exhibited a 200-fold better potency than the original hit compound Specific cancer cell cytotoxicity was confirmed for the most potent compounds
Chemistry Central Journal published new progress about Antiproliferative agents. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Application of 2,3-Dimethoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts