Kim, Michelle B. published the artcileThe Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol, Quality Control of 5653-62-3, the main research area is totarol heterocyclic derivative preparation antimicrobial.
The synthesis and antimicrobial activity of heterocyclic analogs of the diterpenoid totarol, e.g., I, are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogs with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogs do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.
ACS Medicinal Chemistry Letters published new progress about Antibacterial agents. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Quality Control of 5653-62-3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts