Zhu, Sheng-Qing published the artcileDirect and Regioselective C-H Oxidative Difluoromethylation of Heteroarenes, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is difluoromethyl heterocycle preparation; heteroarene regioselective oxidative difluoromethylation.
The difluoromethyl group (CF2H) is of great interest in the area of medicinal chem. However, the investigation of mol. scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into heteroarenes. Herein we disclose a new strategy for the direct introduction of a difluoromethyl group into heteroarenes via the copper-mediated C-H oxidative difluoromethylation of heteroarenes with TMSCF2H. This mild and regioselective method enables the convenient synthesis of a range of difluoromethylated heteroarenes in high yields. The usage of 9,10-phenanthrenequinone (PQ) as an oxidant is critical to the success of this new difluoromethylation reaction.
Journal of the American Chemical Society published new progress about Fluoromethylation (oxidative). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts