Lu, Kui published the artcileSynthesis of Substituted Pyrroles via Copper-Catalyzed Cyclization of Ethyl Allenoates with Activated Isocyanides, Product Details of C16H15NO3S, the main research area is pyrrole preparation; ethyl allenoate isocyanide cyclization copper catalyst; allenoates; copper; cyclization; isocyanides; pyrrole synthesis.
A new method for the synthesis of di- and trisubstituted pyrroles I (R1 = H, CH3, t-Bu, Bn, Ph, etc.; R2 = H, CH3, C2H5, Bn, 4-CH3OC6H4, 4-FC6H4; R3 = Ts, 4-ClC6H4SO2, 4-FC6H4SO2, 4-CH3OC6H4SO2, C6H5SO2) via copper-catalyzed cyclization of Et allenoates with activated isocyanides has been developed. In contrast to related annulation reactions previously reported, this new process features a skeletal rearrangement in which the aryl sulfonyl moiety, which functions as the electron-withdrawing group in the α-carbon of the isocyanide, was found to migrate to the γ-carbon of the starting allenoate in the final product for the first time.
Chemistry – An Asian Journal published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Product Details of C16H15NO3S.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts