Li, Wangyu published the artcileLewis-Acid-Catalyzed Selective Friedel-Crafts Reaction or Annulation between Anilines and Glyoxylates, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is anilines based diarylmethane preparation; aniline glyoxylate Friedel Craft Lewis acid catalyst; oxoimidazolidine diastereoselective preparation; glyoxylate aniline annulation Lewis acid catalyst.
A Lewis-acid-catalyzed selective reaction between anilines and glyoxylates was developed for synthesis of diarylmethanes or oxoimidazolidines. Under the catalysis of AgOTf, a series of anilines-based diarylmethanes I [R = H, 3-F, 3-CN, etc.; R1 = NH2, NHMe, pyrrolidin-1-yl, etc.; R2 = Me, Et, Ph, 4-MeC6H4], including primary, secondary and tertiary anilines were obtained in moderate to good yields. Moreover, stereoselective oxoimidazolidines II [R3 = 4-Cl, 3-CF3, 4-CO2Et, etc.] were performed with the catalysis of Cu(OAc)2·H2O.
Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts