Assaf, Jaber published the artcileReconsidering mass spectrometric fragmentation in electron ionization mass spectrometry – new insights from recent instrumentation and isotopic labeling exemplified by ketoprofen and related compounds, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile, the main research area is electron ionization mass spectrometry isotopic labeling ketoprofen compound.
Rationale : In various fields of chem. analyses, structurally unknown analytes are considered. Proper structure confirmation may be challenged by the low amounts of analytes that are available, e.g. in early stage drug development, in metabolism studies, in toxicol. or in environmental analyses. In these cases, mass spectrometric techniques are often used to build up structure proposals for these unknowns. Fragmentation reactions in mass spectrometry are known to follow definite pathways that may help to assign structural elements by fragment ion recognition. This work illustrates an investigation of fragmentation reactions for gas chromatog./electron ionization mass spectrometric characterization of benzophenone derivatives using the analgesic drug ketoprofen and seven of its related compounds as model compounds Methods : Deuteration and 18O-labeling experiments along with high-resolution accurate mass and tandem mass spectrometry (MS/MS) were used to further elucidate fragmentation pathways and to substantiate rationales for structure assignments. Low-energy ionization was investigated to increase confidence in the identity of the mol. ion. Results : The high-resolution mass analyses yielded unexpected differences that led to reconsideration of the proposals. Site-specific isotopic labeling helped to directly trace back fragment ions to their resp. structural elements. The proposed fragmentation pathways were substantiated by MS/MS experiments Conclusions : The described method may offer a perspective to increase the level of confidence in unknown analyses, where reference material is not (yet) available.
Rapid Communications in Mass Spectrometry published new progress about Gas chromatography-electron ionization mass spectrometry. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts