Lehmann, Johannes published the artcileThe Kondrat’eva Reaction in Flow: Direct Access to Annulated Pyridines, COA of Formula: C10H6N2O, the main research area is annulated pyridine preparation; continuous flow inverse electron demand Kondrateva cycloaddition reaction; cycloaddition reaction continuous flow oxazole cycloalkene.
A continuous flow inverse-electron-demand Kondrat’eva reaction has been developed that provides direct access to cycloalka[c]pyridines from unactivated oxazoles and cycloalkenes. The cycloadditions of both unactivated alkenes and deactivated oxazoles are promoted in continuous flow at elevated temperatures and pressures (230 °C, 750psi). E.g., reaction of 5-phenyloxazole and cyclopentene in presence of TFA gave 55% 4-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine (I). Annulated pyridines obtained by this one-step process are valuable scaffolds for medicinal chem.
Organic Letters published new progress about Cycloalkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, COA of Formula: C10H6N2O.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts