Zhang, Chuan-Tao published the artcileContinuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran, Quality Control of 42872-30-0, the main research area is diaryl ketone preparation continuous flow green chem; aryl Grignard reagent acyl chloride coupling reaction.
An efficient continuous flow sequential synthesis of diaryl ketones RC(O)R1 (R = C6H5, 4-MeOC6H4, thiophen-2-yl, etc.; R1 = 2-MeC6H4, 3-FC6H4, naphthalen-2-yl, etc.) was achieved by coupling of aryl Grignard reagents RMgBr with acyl chlorides R1C(O)Cl in the bio-derived “”green”” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 h), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour-1.
RSC Advances published new progress about Aromatic acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Quality Control of 42872-30-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts