More, Vijaykumar published the artcileThe first organocatalytic asymmetric synthesis of 3-substituted isoindolinones, Name: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is quinine cinchonidine urea thiourea alkaloid catalyst isoindolinone preparation.
Herein the authors describe the first asym. organocatalytic synthesis of 3-substituted isoindolinone derivatives by a convenient aldol-cyclization-rearrangement tandem reaction of malonates with 2-cyanobenzaldehyde. Bifunctional thiourea-cinchona catalysts proved to be particularly effective, giving the title compounds in high yield and moderate-to-good enantiomeric excesses. Moreover an efficient process of reverse crystallization led to a further enrichment up to >99% ee. The synthesis of the target compounds was achieved using N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-cinchonan-9-yl]thiourea, etc. as catalysts in comparison with N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(1S,2S)-2-(dimethylamino)-1-phenylpropyl]thiourea, cupreidine, etc. The title compounds thus formed included (-)-2-(2,3-dihydro-3-oxo-1H-isoindol-1-yl)-1,3-propanedioic acid 1,3-di-Me ester (I).
RSC Advances published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Name: 2-Formyl-4,5-dimethoxybenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts