Andersen, K. E. published the artcileOxadiazoles as bioisosteric transformations of carboxylic functionalities. Part I, COA of Formula: C6H7N3, the main research area is pyrazolopyrimidine pyrrolopyrimidine oxadiazolylpyrazolopyrimidine preparation benzodiazepine receptor.
Cyclocondensation of aminopyrazoles with appropriate 3-(dimethylamino)-1-aryl-2-propen-1-ones gave 51-86% pyrazolo[1,5-a]pyrimidines I (R1 = cyano, CO2Et, R2 = 4-F3CC6H4, Ph, 3-thienyl, etc.). Reaction of nitriles I with hydroxylamine in aqueous ethanol gave crude 56-93% amidoximes which on heating with an acid chloride or anhydride afforded 65-81% oxadiazole derivatives II (R3 = Me, cyclopropyl, CF3, R2 = same). Some pyrrolopyrimidines were also prepared and the prepared compounds were tested as benzodiazepine receptors.
European Journal of Medicinal Chemistry published new progress about Benzodiazepine receptors Role: RCT (Reactant), RACT (Reactant or Reagent). 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, COA of Formula: C6H7N3.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts