Frost, Grant B. published the artcileChemoselectivity for Alkene Cleavage by Palladium-Catalyzed Intramolecular Diazo Group Transfer from Azide to Alkene, Product Details of C7H6N2, the main research area is benzyl alkenyl phenyl carbamoyl azide preparation palladium catalyst chemoselective; benzo dihydroquinazolinone preparation; alkene cleavage; azides; cycloreversion; diazo group transfer; palladium.
A palladium-catalyzed intramol. azide to alkene DGT, which granted chemoselectivity over competing aziridination. The data supported a catalytic cycloreversion mechanism distinct from other known metal-catalyzed azide/alkene reactions: nitrenoid/metalloradical and (3+2) cycloadditions Kinetics experiments revealed an unusual mechanistic profile in which the catalyst was not operative during the rate-controlling step, rather, it was active during the product-determining step. Catalytic DGT was used to synthesize N-heterocyclic quinazolinones, a medicinally relevant structural core. On the competing aziridination and subsequent ring expansion to another N-heterocyclic core structure of interest, benzodiazepinones was also reported.
Chemistry – A European Journal published new progress about Chemoselectivity. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts