Yuan, Shuo published the artcile“”On-Water”” Palladium-Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4-Arylquinazolines, Synthetic Route of 1885-29-6, the main research area is aryl quinazoline preparation green chem; benzonitrile preparation arylboronic acid tandem heterocyclization palladium catalyst; cascade reactions; catalysis; on-water synthesis; palladium; quinazolines.
The quinazoline scaffold is prevalent in pharmaceutically relevant mols. that show diverse biol. activities. An efficient “”on-water”” palladium-catalyzed tandem cyclization reaction from com. available arylboronic acids RB(OH)2 (R = Ph, 3-nitrophenyl, naphthalen-1-yl, etc.) and benzonitriles (E)-2-CN-R1C6H4N=C(R2)N(Me)2 [R1 = H, 5-Me, 4,5-(OMe)2, etc.; R2 = H, Me] that enable the rapid access to 4-arylquinazoline scaffolds I [R3 = H, 7-Me, 6,7-(OMe)2, etc.] in good to excellent yields (45 examples, up to 98% yield) was reported. This protocol has shown good functional group tolerance and broad substrate scope. The reaction was also performed on a gram scale and successfully applied to the synthesis of the highly potent and selective PI3Kδ inhibitor II, showing the practicability and synthetic utility of the protocol. In this reaction, the quinazoline scaffold I is efficiently constructed with the simultaneous formation of one C-C bond and one C-N bond. Collectively, the protocol could serve as an alternative strategy to synthesize biol. important quinazoline scaffolds.
Chemistry – A European Journal published new progress about Bond formation catalysts (C-N, C-C). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts