Wu, Xiang published the artcileGold-catalyzed cyclization of 1-(2′-azidoaryl)propynols: synthesis of polysubstituted 4-quinolones, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinolone preparation; azidoaryl propynol cyclization gold catalyst.
An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones I (R1 = C6H5, 4-NCC6H4, 4-FC6H4, etc.; R2 = H, 7-Me, 6-Br, etc.) from 1-(2′-azidoaryl)propynols II is described. The reaction underwent an intramol. nucleophilic attack of the azide group to the Au-activated triple bonds in a 6-endo-dig manner and subsequent gold-assisted expulsion of N2 to furnish an α-imino gold carbene intermediate, which triggers a 1,2-carbon migration and finally is converted to 2,3-disubstituted 4-quinolone.
Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts