Wilkovitsch, Martin published the artcileA Cleavable C2-Symmetric trans-Cyclooctene Enables Fast and Complete Bioorthogonal Disassembly of Molecular Probes, SDS of cas: 100-70-9, the main research area is bioorthogonal disassembly mol fluorescent probe trans cyclooctene cell imaging.
Bioorthogonal chem. is bridging the divide between static chem. connectivity and the dynamic physiol. regulation of mol. state, enabling in situ transformations that drive multiple technologies. In spite of maturing mechanistic understanding and new bioorthogonal bond-cleavage reactions, the broader goal of mol. ON/OFF control has been limited by the inability of existing systems to achieve both fast (i.e., seconds to minutes, not hours) and complete (i.e., >99%) cleavage. To attain the stringent performance characteristics needed for high fidelity mol. inactivation, we have designed and synthesized a new C2-sym. trans-cyclooctene linker (C2TCO) that exhibits excellent biol. stability and can be rapidly and completely cleaved with functionalized alkyl-, aryl-, and H-tetrazines, irresp. of click orientation. By incorporation of C2TCO into fluorescent mol. probes, we demonstrate highly efficient extracellular and intracellular bioorthogonal disassembly via omnidirectional tetrazine-triggered cleavage.
Journal of the American Chemical Society published new progress about Bioorthogonal reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts