Shit, Sudip published the artcileSynthesis of Spiro[furan-2,1′-isoindolin]-3′-ones from 2-(4-Hydroxybut-1-yn-1-yl)benzonitriles and Aryl Aldehydes under the Action of Triflic Acid, Quality Control of 1885-29-6, the main research area is spiro furanisoindolinone diastereoselective preparation; hydroxybutynyl benzonitrile aryl aldehyde Prins Ritter ring opening addition.
The synthesis of spiro[furan-2,1′-isoindolin]-3′-ones I [R1 = H, 5-Me, 6-Cl, 6-Br; R2 = H, Me, Et; Ar = Ph, 4-FC6H4, 2-BrC6H4, etc.] from 2-(4-hydroxybut-1-yn-1-yl)benzonitriles and aryl aldehydes was demonstrated. It involved the initial formation of dihydrofuranylideneisoindolinone via intramol. sequential Prins and Ritter reactions, followed by the ring opening of the furanyl moiety to generate N-acyliminium ions and alcs. for the final cyclization reaction, and the spiro-cyclic compounds were produced in moderate to good yields. It was a one-pot, three-component reaction in which one new quaternary carbon, two five-membered rings, one C-N bond, two C-O bonds and one C-C bond are formed. The reaction was carried out with a Bronsted acid from 0°C to room temperature within a short period of time.
Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts