Satyam, Killari published the artcileThe base-free Van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives, Category: nitriles-buliding-blocks, the main research area is dihydro imidazopyridoindole preparation green chem; dihydrocarboline tosylmethyl isocyanide Van Leusen reaction.
Construction of substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I (R = H, Et, Ph, etc.; R1 = H, 8-Br; R2 = H, 6-Ph, 5-Me, etc.) has been demonstrated on water under base-free conditions. The reaction of p-toluenesulfonylmethyl isocyanides 4-CH3C6H4SO2CH(R)NC and dihydro β-carboline imines II (R3 = H, 6-Br; R4 = H, 4-Ph, 3-Me, etc.) furnished the corresponding substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.
Organic & Biomolecular Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts