Perez-Medrano, Arturo published the artcileSynthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine as P2X7 antagonists, Recommanded Product: 2-Morpholinobenzonitrile, the main research area is benzyl dichlorophenyl tetrazol amine preparation P2X7 antagonist human.
Synthesis and biol. evaluation of a novel class of substituted N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine derivatives resulted in the identification of potent P2X7 antagonists. These compounds were assayed for activity at both the human and rat P2X7 receptors. On the benzyl moiety, a variety of functional groups were tolerated, including both electron-withdrawing and electron-donating substituents. Ortho-substitution on the benzyl group provided the greatest potency. The ortho-substituted analogs showed approx. 2.5-fold greater potency at human compared to rat P2X7 receptors.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Recommanded Product: 2-Morpholinobenzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts