Nishino, Mayuko published the artcileCopper-Mediated C-H/C-H Biaryl Coupling of Benzoic Acid Derivatives and 1,3-Azoles, Application of 4-(5-Oxazolyl)benzonitrile, the main research area is biaryl preparation; amide aromatic heteroaromatic coupling azole copper mediated.
A precious metal-free copper-mediated intermol. diaryl coupling of aromatic and heteroaromatic amides XC(O)NHQ (Q = 8-quinolinyl; X = Ph, 3-MeC6H4, 4-t-BuC6H4, 1-naphthyl, 2-furyl, 2-thienyl, 1-methyl-2-indolyl, 4-pyridyl, etc.) with 1,3-azoles R-H (R = 2-benzoxazolyl, 5-phenyl-2-oxazolyl, 2-thiazolyl, 1-methyl-2-imidazolyl, etc.) to provide the corresponding biaryls o-RXC(O)NHQ has been developed. The key to success is the installation of an amide-based bidentate coordinating group, which can be easily transformed into an ester group after the coupling reaction. Kinetic studies indicated that the rate-limiting step is the aromatic C-H bond cleavage of the N-(8-quinolinyl) amides.
Angewandte Chemie, International Edition published new progress about Arylation. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Application of 4-(5-Oxazolyl)benzonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts