Lee, Taegyo published the artcileRhodium-Catalyzed Enantioselective Silylation of Cyclopropyl C-H Bonds, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile, the main research area is rhodium catalyzed enantioselective silylation cyclopropylmethanol ethylsilane; chiral hydroxycyclopropanol preparation crystal structure; mol structure chiral hydroxycyclopropanol; carbon hydrogen bond activation silylation cyclopropylmethanol rhodium catalyst; kinetic isotope effect silylation cyclopropylmethanol rhodium catalyst; C−H activation; asymmetric catalysis; cyclopropanes; rhodium; silylation.
Hydrosilyl ethers, generated in situ by the dehydrogenative silylation of cyclopropylmethanols with diethylsilane, undergo asym., intramol. silylation of cyclopropyl C-H bonds in high yields and with high enantiomeric excesses in the presence of a Rh catalyst derived from a Rh precursor and the bisphosphine (S)-DTBM-SEGPHOS. The resulting enantioenriched oxasilolanes are suitable substrates for the Tamao-Fleming oxidation to form cyclopropanols with conservation of the ee value from the C-H silylation. Preliminary mechanistic data suggest that C-H cleavage probably is the turnover-limiting and enantioselectivity-determining step.
Angewandte Chemie, International Edition published new progress about C-H bond activation. 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Safety of 1-(4-Fluorophenyl)cyclopropanecarbonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts