Kumar, Ankit published the artcileBase-Promoted Synthesis of Polysubstituted 4-Aminoquinolines from Ynones and 2-Aminobenzonitriles under Transition-Metal-Free Conditions, Application In Synthesis of 1885-29-6, the main research area is aminoquinoline preparation; ynone aminobenzonitrile tandem aza Michael addition intramol annulation; aminonaphthyridine preparation; aminonicotinonitrile ynone aza Michael addition intramol annulation.
A transition-metal-free and base-promoted one-pot reaction of ynones with 2-aminobenzonitriles was described. The reaction was initiated through sequential aza-Michael addition/intramol. annulation to afford multisubstituted 4-aminoquinolines I [R1 = Ph, 2-thienyl, 4-MeC6H4, etc.; R2 = Ph, 4-MeC6H4, 3-thienyl, etc.; R3 = H, 6,7-di-MeO, 6-F, etc.; X = CH] and 4-amino-1,8-naphthyridines I [X = N] in good to excellent yields. Operational simplicity, high atom-economy with broad substrate scope made this protocol more attractive. Also, the gram-scale synthesis and further transformation of the product were studied. Addnl., 2-haloarylyones as substrate provided N-arylquinolones/1,8-naphthyridin-4-ones II [R4 = H, 4-Me, 4,5-di-MeO; Y = CH, N] as the sole product via the SNAr mechanism.
Advanced Synthesis & Catalysis published new progress about Aza-Michael reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts