Kobayashi, Kazuhiro published the artcileA Convenient Synthesis of 2,3-Dihydro-3-methylidene-1H-isoindol-1-ones by Reaction of 2-Formylbenzonitriles with Dimethyloxosulfonium Methylide, Quality Control of 1013112-48-5, the main research area is formyl benzonitrile dimethyloxosulfonium methylide heterocyclization; dihydro methylidene isoindolone preparation.
A facile method for the synthesis of 2,3-dihydro-3-methylidene-1H-isoindol-1-one and its derivatives carrying substituent(s) at C(5) and/or C(6) has been developed. The reaction of 2-formylbenzonitrile with dimethyloxosulfonium methylide, generated by the treatment of trimethylsulfoxonium iodide with NaH in DMSO/THF at 0°, resulted in the formation of 2,3-dihydro-3-methylidene-1H-isoindol-1-one (I) in 77% yield. Similarly, six 2-formylbenzonitriles carrying substituent(s) at C(4) and/or C(5), also gave the corresponding expected products in comparable yields.
Helvetica Chimica Acta published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-cyano). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Quality Control of 1013112-48-5.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts