Hu, Xiaoping published the artcileNickel-Catalyzed β-Regioselective Amination/Cyclization of Ynamide-Nitriles with Amines: Synthesis of Functionalized 3-Aminoindoles and 4-Aminoisoquinolines, Application In Synthesis of 1885-29-6, the main research area is indole amino aryliminobenzyl preparation; ynamide nitrile regioselective amination cyclization aromatic amine nickel catalyst.
A highly regioselective nickel/Lewis acid catalyzed amination/cyclization of ynamide-nitriles I (R1 = Ph, 4-MeOC6H4, 2-FC6H4, 2-thienyl, etc.; R2 = Me, 4-FC6H4, 4-MeC6H4, 4-MeOC6H4) with amines R3NH2 (R3 = Ph, 4-FC6H4, 3,5-Me2C6H3, 1-naphthyl, 2-thiazolyl, etc.) involving β-addition has been developed. The reaction offers an attractive and efficient route for the synthesis of 3-aminoindoles II. A 4-aminoisoquinoline was also obtained via this approach. The R2SO2-group on the ynamide acts as a directing group to produce the alkenyl nickel species with high regioselectivity.
Organic Letters published new progress about Amination catalysts. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts