Geigle, Stefanie N. published the artcileDevelopment of DNA-Compatible Van Leusen Three-Component Imidazole Synthesis, Application In Synthesis of 263389-54-4, the main research area is DNA compatible three component imidazole synthesis.
DNA-encoded libraries (DELs) have generated recent interest due to their ability to provide new small mol. ligands for pharmaceutically important proteins. The chem. diversity of DELs determines their ability to provide potent, novel, and drug-like chem. matter, and DEL chem. diversity is limited by the scope of DNA-compatible chem. reactions. Herein, the one-pot three-component Van Leusen chem. is applied to DEL synthesis, providing the first reported DNA-compatible method to generate novel highly functionalized imidazoles.
Organic Letters published new progress about van Leusen three-component reaction. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application In Synthesis of 263389-54-4.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts