Fereidoonnezhad, Masood published the artcileDesign, synthesis, molecular docking, biological evaluations and QSAR studies of novel dichloroacetate analogues as anticancer agent, COA of Formula: C7H6N2, the main research area is aryl dichloroacetamide preparation antitumor mol docking QSAR; dichloroacetate aryl preparation antitumor mol docking QSAR.
In this study, a series of novel N-aryl-2,2-dichloroacetamide ArNHC(O)CHCl2 (Ar = 9,10-dioxo-9,10-dihydroanthracen-1-yl (I), pyridin-2-yl, thiazol-2-yl, etc.) and aryl-2,2-dichloroacetate derivatives Ar1OC(O)CHCl2 (Ar1 = 2-hydroxyphenyl, 4-fluorophenyl, 3-methoxyphenyl, etc.) were designed and synthesized. Their cytotoxic activities against various human cancer cell lines including A549, HCA-7, MCF-7, MDA-MB-231, KB and SKOV3 were evaluated. These compounds showed satisfactory potencies with much higher anticancer activity than the parent compound DCA, against the studied cancer cell lines. Mol. docking studies were also done to find their binding site and types of their interactions with PDKs isoenzymes. Among the synthesized compounds, compound I can also induce A549 cells apoptosis. Therefore, compound I might have a potential value for further study in drug development. QSAR studies of this class of compounds were also explored using a collection of chemometrics methods.
Journal of Molecular Structure published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (dichloro, aryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts