Baechle, Felix published the artcileGlycoconjugated Phthalocyanines as Photosensitizers for PDT – Overcoming Aggregation in Solution, Synthetic Route of 91-15-6, the main research area is glycoconjugated zinc phthalocyanine complex preparation CD spectra fluorescence; cytotoxicity activity glycoconjugated zinc phthalocyanine complex.
A series of new glycoconjugated zinc(II) phthalocyanines (Pcs) was synthesized and fully characterized. The major focus of the structural design for these new Pcs was upon the reduction of aggregate formation in solution Therefore, the aglycons of the Pc-linked sugars, the number and the position of the carbohydrate substituents on the Pc and the linker between sugar and Pc were varied. Specifically, di- and octasubstituted zinc(II) phthalocyanines with triazole and C-C linkages were synthesized and their aggregation behavior was investigated by UV/visible-, CD- and NMR spectroscopy. The C-glycosidically decorated Pcs described here are the first compound types of this kind. These C-glycosidically substituted Pcs not form any aggregation in solution and hence, are considered to be potential photosensitizers in photodynamic therapy. All Pcs synthesized in this study exhibited excellent photophys. properties for use as photosensitizers (λmax > 675 nm with εmax > 105 M-1 cm-1). Preliminary cytotoxicity studies of the Pcs presented here showed that all Pcs are photodynamically effective.
European Journal of Organic Chemistry published new progress about Circular dichroism. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts