On January 24, 2020, Zhuo, Junrui; Yuan, Weicheng; Zhao, Jianqiang; Quan, Baoxue; Du, Anni; Wang, Keke published a patent.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the patent was Polycyclic heterocyclic compound synthesized using water as medium, its preparation method, and application. And the patent contained the following:
A simple and environmentally-friendly method of preparing a polycyclic heterocyclic compound having improved air-stability, suitability for wide application in photoluminescence materials, drug screening and pharmaceutical industry, and mild reaction conditions is provided. The polycyclic heterocyclic compound is represented by Formula I, where X is O, S, and N-R, Y is H, CH2, OCH2, (CH2)2, (CH2)3, and Ar is alkyl, halogen or aryl-substituted benzene ring, furan ring, thiophene ring, and R1 is hydrogen, alkyl, halogen, and aryl group. The preparation method of the polycyclic heterocyclic compound comprises: using water as a reaction medium and under the regulation of a base, adding dicyanoolefin synthesizer and 2-nitroheteroarom. or 3-nitroheteroarom. hydrocarbon and performing alkali-promoted [4+2] olefin cyclization reaction to obtain the final product. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile
The Article related to polycyclic heterocyclic compound synthesis water medium, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts