On August 31, 1980, Sandberg, Rune; Domeij, Karl-Erik; Stening, Goeran; Willman, Nils; Aekerman, Bengt published an article.Recommanded Product: 2510-01-2 The title of the article was N-Aminoalkylsuccinimides as local anesthetics. III. 1,2,3,4-Tetrahydronaphthalene-2-, indane-1-, and indane-2-spiro-3′-pyrrolidine-2-‘5-diones. And the article contained the following:
In a series of N-aminoalkylindanespirosuccinimides, compounds with the spiro-atom in the 2-position possessed a higher local anesthetic potency and toxicity than the corresponding spiro-1-indanes. Similar differences in potency and toxicity were seen between tetralin-1- and tetralin-2-spirosuccinimides. Most of the new compounds were more active by topical application than lidocaine but also more toxic. The tetrahydronaphthalene derivative I [75639-71-3] compared favorable with prilocaine both regarding low toxicity and good nerve blocking properties but displayed local irritation. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Recommanded Product: 2510-01-2
The Article related to naphthalenespiropyrrolidinedione local anesthetic, indanspiropyrrolidinedione local anesthetic, aminoalkylsuccinimide local anesthetic, Pharmacodynamics: Effects On Mammals and other aspects.Recommanded Product: 2510-01-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts