On May 12, 2011, Hallman, Jason; Laudeman, Christopher; Liu, Ronggang; Miller, Aaron; Moore, Michael Lee; Dock, Steven; Musso, David; Parrish, Cynthia published a patent.Formula: C7H3ClN2O2 The title of the patent was Benzimidazoles as fatty acid synthase inhibitors and their preparation and use for the treatment of cancer. And the patent contained the following:
The invention relates to benzimidazole derivatives of formula I, which are fatty acid synthase inhibitors and which are useful in the treatment of cancer. Compounds of formula I wherein each R1 is independently halo, C1-6 alkyl, alkoxy, CN, etc.; R2 is (un)substituted aryl and (un)substituted heteroaryl; R3 is amino, alkylamino, dialkylamino, etc.; each R4 is C1-6 alkyl, alkoxy, OH and halo; each Y is independently C and N; n is 0 to 4; m is 0 to 4; provided that at least two Y are C; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their fatty acid synthase inhibitory activity. From the assay, it was determined that compound II exhibited a pIC50 value of 7.26. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Formula: C7H3ClN2O2
The Article related to benzimidazole preparation fatty acid synthase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Formula: C7H3ClN2O2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts