Goud, S. Banuprakash; Guin, Soumitra; Prakash, Meher; Samanta, Sampak published an article in 2022, the title of the article was Cu(OAc)2/DABCO-mediated domino reaction of vinyl malononitriles with cyclic sulfamidate imines: access to 6-hydroxyaryl-2-aminonicotinonitriles.Category: nitriles-buliding-blocks And the article contains the following content:
A novel Cu(II)-salt/DABCO-mediated one-pot access to a myriad of highly substituted biol. relevant 2-aminonicotinonitriles possessing a resourceful phenolic moiety, e.g., I with satisfactory yields is reported. This method involves cyclic sulfamidate imines, e.g., benzo[e][1,2,3]oxathiazine 2,2-dioxide as 1C1N sources and different kinds of acyclic/cyclic vinyl malononitriles, e.g., 2-(1-phenylethylidene)malononitrile as 4C sources for pyridine synthesis via a vinylogous Mannich-cycloaromatization sequence process, creating two new C-N bonds under mild conditions. Importantly, this de novo strategy is applicable to gram-scale syntheses, underlining the method’s practicability and allowing for a wide range of substrates with excellent functional group tolerance. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks
The Article related to hydroxyaryl aminonicotinonitrile preparation, cyclic sulfamidate imine vinyl malononitrile domino vinylogous mannich cycloaromatization, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts