On April 16, 2021, Reutskaya, Elena; Sapegin, Alexander; Peintner, Stefan; Erdelyi, Mate; Krasavin, Mikhail published an article.Synthetic Route of 34662-29-8 The title of the article was Sulfur Oxidation Increases the Rate of HIRE-Type [1.4]Thiazepinone Ring Expansion and Influences the Conformation of a Medium-Sized Heterocyclic Scaffold. And the article contained the following:
The hydrated imidazoline ring expansion (HIRE-type) reaction was investigated for a series of di(hetero)arene-fused [1.4]thiazepinones in comparison with their sulfone counterparts. The sulfones were found to undergo ring expansion at a much higher rate compared to the thioethers, much in line with the current mechanistic understanding of the process. Moreover, the amide bond cis- and trans-isomers of the ring-expanded products were found, in the case of sulfones, to be stabilized through an intramol. hydrogen bond. The latter phenomenon was studied in detail by NMR experiments and corroborated by X-ray crystallog. information. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8
The Article related to thiazepinone hydrated imidazoline ring expansion conformation sulfone, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Synthetic Route of 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts