On December 31, 1985, Makosza, Mieczyslaw; Wenall, Maria; Golinski, Miroslaw; Kinowski, Andrzej published an article.Application of 13544-06-4 The title of the article was Reactions of organic anions. Part 130. Specific ortho-cyanomethylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen. And the article contained the following:
The reactions of 3-RC6H4NO2 (I, R = MeO, CF3, NO2, MeSO2 halo, cyano) with ClCH2CN (II), PhOCH2CN, and Me2NCS2CH2CN yielded products substituted ortho to the NO2 group. Ortho substitution also resulted in the reactions of II with o- and p-substituted nitrobenzenes. Thus, II and I (R = 2-Cl) in THF containing Me3COK at -10° to -20° gave 10% 2,3-O2N(Cl)C6H3CH2CN. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4
The Article related to cyanomethylation nitroarene regiochem, nucleophile substitution nitroarene regiochem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitro and Nitroso Compounds and other aspects.Application of 13544-06-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts