Liu, Lu; Li, Lei; Mao, Shukuan; Wang, Xin; Zhou, Ming-Dong; Zhao, Yu-long; Wang, He published an article in 2020, the title of the article was Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds.Electric Literature of 13544-06-4 And the article contains the following content:
A novel copper-catalyzed domino reaction between o-alkenyl aromatic isocyanides and diazo compounds was developed under mild reaction conditions. Various o-alkenyl aromatic isocyanides were prepared from readily available reactants. The reaction provided a general and efficient method for synthesis of pyrazolo[1,5-c]quinazolines I [R1 = cyclohexyl, 2-thienyl, 2-naphthyl, etc.; R2 = H, 8-MeO, 7-Cl, etc.; R3 = OEt, OBn, 4-ClC6H4, etc.] by the formation of two rings and three new bonds in a single step from readily available acyclic starting materials. A mechanism involving a tandem (3+2) cyclization/elimination/intramol. aza-addition sequence was proposed. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Electric Literature of 13544-06-4
The Article related to pyrazoloquinazoline preparation, ortho alkenyl aryl isocyanide diazo compound tandem copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 13544-06-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts