On May 26, 2011, Kim, Seon Mi; Lee, Min Hee; Kim, Jae Sun; Jung, Hoe Chul; Lee, So Young; Lee, Soo Min; Kim, Eun Jeong; Park, Eui Sun; Park, Sung Hoon; Lee, Bong Yong; Um, Key An published a patent.COA of Formula: C8H5BrFN The title of the patent was Preparation of gonadotropin releasing hormone receptor antagonists. And the patent contained the following:
Compound I [X = N-containing non-aromatic heterocycle or substituted non-aromatic heterocycle; Y = -(CR9aR9b)r-Z-R4; B = NR1R2 or OR1 where r = 0, 1, 2, 3; n = 2, 3, 4; Z = direct bond, O, S, CO, etc.; D = Q1, Q2, Q3, etc. where E = O, S, NR8; R1, R2 = independently H, (un)substituted C1-10 alkyl, (un)substituted C3-10 cycloalkyl, (un)substituted C6-12 aryl, etc.; R3a, R3b = independently H, (un)substituted C1-10 alkyl, (un)substituted C3-10 cycloalkyl, C1-10 alkoxy, etc.; R4 = H, substituted C1-10 alkyl, C3-10 cycloalkyl, (un)substituted C6-12 aryl, etc.; R5 = H, halogen, (un)substituted C1-6 alkyl, (un)substituted C3-10 cycloalkyl, etc.; R6 = H, (un)substituted C1-6 alkyl, (un)substituted C3-10 cycloalkyl, etc.;R8 = H, cyano, (un)substituted C1-10 alkyl, etc.; R9a, R9b = independently H, acyl, hydroxy, halogen, etc.; its stereoisomers or pharmaceutically acceptable salts] was prepared For example, II was prepared in a multistep synthesis. Compound I was claimed useful as gonadotropin releasing hormone (“”GnRH””) (known as LH releasing hormone) receptor antagonists for treatment of prostatic cancer, uterine cancer, and breast cancer, etc. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN
The Article related to preparation gonadotropin releasing hormone receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C8H5BrFN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts