On April 17, 2014, Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T. published a patent.Electric Literature of 337965-61-4 The title of the patent was Preparation of benzamides as P2X7 receptor antagonists. And the patent contained the following:
The title compounds I [R1 = Ph, pyridyl, pyrazinyl, etc.; R2 = cycloalkyl, alkoxy, Ph, etc.; R3 = H, F, alkyl, fluoroalkyl; or R2 and R3 can be combined with the carbon to which they are attached to form cyclohexyl, piperazinyl, piperidinyl, etc.; R4 = halo, fluoroalkyl, CN, etc.; R5 = halo, alkyl, fluoroalkyl, etc.; n = 0-3], useful in the treatment of diseases related with the activity of P2X7 receptor, were prepared For example, amidating [4-(4-chloro-phenyl)-tetrahydro-pyran-4-yl]-methylamine with 2,3-dimethylbenzoyl chloride afforded 66% II. Compounds I were tested in vitro for their ability to act as antagonists to the P2X7 receptor (data given for representative compounds I). Pharmaceutical composition comprising compound I is disclosed. The experimental process involved the reaction of 2-(6-Fluoropyridin-3-yl)acetonitrile(cas: 337965-61-4).Electric Literature of 337965-61-4
The Article related to benzamide preparation p2x7 receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 337965-61-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts