On January 31, 2009, Kaspady, Mohamed; Narayanaswamy, Venugopala Katharigatta; Raju, Mohana; Rao, Gopal Krishna published an article.Synthetic Route of 34662-29-8 The title of the article was Synthesis, antibacterial activity of 2,4-disubstituted oxazoles and thiazoles as bioisosteres. And the article contained the following:
Two series of 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole (2a-k) and thiazole (4a-k) mol. scaffolds containing divalent bioisosteres, viz., oxygen and sulfur were synthesized by condensing substituted amides and thioamides with substituted phenacyl bromide in absolute ethanol medium. The structure of newly synthesized compounds was characterized by anal. and spectral (IR, 1H-NMR, 13C-NMR and LC-MS) methods. The synthesized compounds were evaluated for qual. (zone of inhibition) and quant. antibacterial activity (MIC) by agar cup plate and micro-titration methods, resp. Preliminary pharmacol. observations revealed that some of the substituents such as 2-alkyl and heteroaryl at second position, chloro and bromo at the fourth position of the aryl moiety and a divalent sulfur atom in the five-membered heterocyclic ring system influenced significantly the antibacterial activity when compared to its bioisostere counterpart 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1,3-oxazole systems. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Synthetic Route of 34662-29-8
The Article related to antibacterial oxazole thiazole preparation sar, Microbial, Algal, and Fungal Biochemistry: Antimicrobial Sensitivity and other aspects.Synthetic Route of 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts