On August 20, 2014, Han, Shiqing; Tong, Yao; Pan, Qiang; Jiang, Zengqiang; Miao, Dazhuang published a patent.COA of Formula: C7H3ClN2O2 The title of the patent was A synthetic method for 2-substituted benzothiazole derivatives. And the patent contained the following:
The invention relates to a process for the preparation of 2-substituted benzothiazole derivatives via heterocyclization of 2-halogenated nitrobenzene with elemental sulfur and aliphatic amines. For instance, 2-phenyl-benzothiazole was prepared from 1-chloro-2-nitrobenzene, sulfur, and benzylamine in 76% yield as a white solid. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2
The Article related to benzothiazole preparation heterocyclization halonitrobenzene benzylamine sulfur, heterocyclization and other aspects.COA of Formula: C7H3ClN2O2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts