On December 7, 2016, Gao, Yuzhe; Wang, Guocheng published a patent.Electric Literature of 1261686-95-6 The title of the patent was Preparation of xanthines as DPP-IV inhibitors. And the patent contained the following:
The invention relates to xanthine derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their as DPP-IV inhibitors for treating type II diabetes. For instance, the invention compound I was prepared via substitution of 8-bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione with 1-bromo-2-butyne followed by substitution with 2-(bromomethyl)-6-fluoro-benzonitrile, substitution with (R)-3-(Boc-amino)piperidine, and hydrolysis. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).Electric Literature of 1261686-95-6
The Article related to xanthine preparation antidiabetic dipeptidyl peptidase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Electric Literature of 1261686-95-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts