On June 11, 2020, Fu, Bang; Li, Yinlong; Ren, Wei; Chen, Jie; Liu, Xiangyong; Wang, Jiabing; Ding, Lieming published a patent.Recommanded Product: 882978-62-3 The title of the patent was Preparation of substituted pyrazolopyrimidines as tyrosine kinase inhibitors, compositions and methods thereof. And the patent contained the following:
The invention relates to compounds of formula I and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, methods of using the compounds as Trk inhibitors, and pharmaceutical compositions comprising such compds; their preparation and use in treating cancer. Compounds of formula I, wherein ring A is C5-6 heterocyclyl; ring B is 5-membered aromatic heterocyclyl; X and Z are independently C, N, O, and S; Y is C and N;R1 is absent, H, and C1-8 alkyl; R2 is H, C1-4 alkyl-NH2, C0-4 alkyl-OH, etc.; R3 absent, C3-10 heterocyclyl; R2 and R3 can be taken together to form 5- to 6-membered carbocyclyl, heterocyclyl, aryl, etc.; R4 is (un)substituted 5- to 6-membered heteroaryl, and isomerides, stereoisomers, tautomers, pharmaceutically acceptable salts, prodrugs, chelates, non-covalent complexes, and solvates thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their tyrosine kinase inhibitory activity (some data given). The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Recommanded Product: 882978-62-3
The Article related to substituted pyrazolopyrimidine tyrosine kinase inhibitor preparation treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 882978-62-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts