On December 19, 2019, Focken, Thilo; Burford, Kristen Nicole; Lofstrand, Verner Alexander; Wilson, Michael Scott; Zenova, Alla Yurevna published a patent.Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile The title of the patent was Preparation of benzenesulfonamide compounds and their use as therapeutic agents. And the patent contained the following:
This invention is directed to benzenesulfonamide compounds of formula I, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels (Nav1.6), such as epilepsy and/or epileptic seizure disorders. Compounds of formula I wherein m and n are independently 1 and 2; R1, R3a, R3b and each R4 are independently H and alkyl; R2 is thiazolyl, isothiazolyl and isoxazolyl; R5 is halo; each R6 is independently halo and alkoxy, provided that at least one R6 is alkoxy; R7 is azabicyclo[2.2.1]heptanylalkyl; R7 is ((methyl)(prop-2-yl)amino)alkyl when n is 2; and stereoisomers, enantiomers, tautomers, mixtures, pharmaceutically acceptable salts, solvates and prodrugs thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their voltage-gated sodium channel inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 0.015 μM, > 30.00 μM and 9.603 μM towards Nav1.6, Nav1.5 and Nav1.1, resp. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile
The Article related to benzenesulfonamide preparation voltage gated sodium channel inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts