On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Safety of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of aminoethoxybenzoxazole derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:
Title compounds I [X = S or O; R1 = H, alkyl, CF3, OH , etc.; R2 = H, alkyl, halo, or CN; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)saturated, (un)substituted carbon chain wherein one carbon atom may optionally be replaced with a N atom; Ar = aryl or heteroaryl], and their pharmaceutically acceptable salts, are prepared and disclosed to possess capability of both serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. Thus, e.g., II was prepared by reaction of 2-(4-iodobutoxy)benzonitrile with the corresponding amine (preparation given). I are evaluated by dopamine-D2 and 5-HT reuptake binding assays, e.g., II demonstrate pKi values of 7.9 and 7.4 resp. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile
The Article related to aminoethoxy benzoxazole preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent aminoethoxybenzoxazole amine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts